But even from such calamities life is by no means free; a thousand ills incurable, a thousand losses irreparable, a thousand difficulties insurmountable are known, or will be known, by all the sons of men. Native deformity cannot be rectified, a dead friend cannot return, and the hours of youth trifled away in folly, or lost in sickness, cannot be restored.
–Dr. Samuel Johnson, “A Remedy for Grief,” The Rambler #52
[Allen Ginsberg defined the Yiddish word tsores as “serious difficulty” in his collection of essays, Deliberate Prose, p. 362.]